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W H Irwin McLean Selected Research

Keratin-12 (Keratin 12)

3/2016Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy.
5/2014siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
1/2013Allele-specific siRNA silencing for the common keratin 12 founder mutation in Meesmann epithelial corneal dystrophy.

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W H Irwin McLean Research Topics

Disease

45Atopic Dermatitis (Atopic Eczema)
12/2018 - 04/2006
17Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)
03/2012 - 03/2006
14Eczema
03/2014 - 03/2007
13Pachyonychia Congenita (Jadassohn-Lewandowsky Syndrome)
12/2017 - 10/2006
11Asthma (Bronchial Asthma)
07/2013 - 06/2006
6Inborn Genetic Diseases (Disease, Hereditary)
01/2018 - 10/2002
6Ichthyosis (Xeroderma)
11/2017 - 10/2002
5Psoriasis (Pustulosis Palmaris et Plantaris)
10/2018 - 08/2007
4Dermatitis
11/2015 - 10/2013
4Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
01/2015 - 02/2002
3Hereditary Corneal Dystrophies
03/2016 - 02/2014
3Juvenile Epithelial of Meesmann Corneal Dystrophy
03/2016 - 01/2011
3Hypersensitivity (Allergy)
11/2015 - 01/2011
3Skin Diseases (Skin Disease)
12/2014 - 05/2008
3Peanut Hypersensitivity (Peanut Allergy)
10/2014 - 03/2011
3Ectodermal Dysplasia (Aplasia Cutis Congenita)
10/2011 - 03/2002
3Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara)
10/2011 - 03/2003
3Inflammation (Inflammations)
09/2009 - 10/2008
3Poikiloderma of Kindler
06/2005 - 07/2003
2Alopecia (Baldness)
07/2012 - 02/2009
2Epidermolytic Palmoplantar Keratoderma
06/2012 - 03/2006
2X-Linked Ichthyosis (Ichthyosis, X Linked)
12/2011 - 12/2007
2pseudofolliculitis barbae
10/2011 - 03/2004
2Burnett Schwartz Berberian syndrome
07/2008 - 08/2006
1Thrombocytopenia (Thrombopenia)
11/2017
1Nevus (Nevi)
01/2017
1Erythema
04/2016
1Food Hypersensitivity (Food Allergy)
04/2016
1Corneal Opacity
03/2016
1Wasting Syndrome (Wasting Disease)
11/2015
1Cheilitis
03/2015
1Keratosis
03/2015
1Disease Progression
01/2015
1Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa)
01/2015
1Lattice corneal dystrophy type 1
02/2014
1Nonepidermolytic Palmoplantar Keratoderma
08/2013
1Epidermolysis Bullosa
03/2012
1Monilethrix
10/2011
1Eye Diseases (Eye Disease)
01/2011
1Hyperkeratosis of the palms and soles and esophageal papillomas
02/2010
1Pancreatic Neoplasms (Pancreatic Cancer)
05/2009

Drug/Important Bio-Agent (IBA)

55Filaggrin ProteinsIBA
12/2018 - 03/2006
20Keratins (Keratin)IBA
03/2016 - 02/2002
13Proteins (Proteins, Gene)FDA Link
01/2018 - 05/2002
9Small Interfering RNA (siRNA)IBA
05/2014 - 10/2006
6AllergensIBA
04/2016 - 10/2008
3Keratin-6 (Keratin 6A)IBA
12/2017 - 03/2008
3Keratin-12 (Keratin 12)IBA
03/2016 - 01/2013
3Desmoglein 1IBA
11/2015 - 05/2002
3Desmoplakins (Desmoplakin)IBA
11/2015 - 02/2002
3NucleotidesIBA
05/2011 - 10/2006
3Keratin-1IBA
03/2006 - 05/2002
2Messenger RNA (mRNA)IBA
01/2018 - 05/2009
2EnzymesIBA
11/2017 - 09/2002
2CytokinesIBA
10/2013 - 04/2012
2Keratin-5 (Keratin 5)IBA
10/2011 - 02/2007
2Immunoglobulin E (IgE)IBA
03/2011 - 05/2009
2Biological ProductsIBA
09/2009 - 10/2008
2Connexin 30IBA
11/2003 - 03/2002
1ponesimodIBA
10/2018
1CeramidesIBA
11/2017
1Keratin-13 (Keratin 13)IBA
01/2017
1CalpainIBA
01/2017
1Complement Factor B (Factor B)IBA
01/2017
1ChlorineIBA
01/2016
1calpastatinIBA
03/2015
1EtretinateFDA Link
01/2015
1Collagen Type VIIIBA
01/2015
12-Oxoglutarate 5-Dioxygenase Procollagen-Lysine (Lysyl Hydroxylase)IBA
01/2015
1Dust (House Dust)FDA Link
10/2014
1EmollientsIBA
10/2014
1Aquaporins (Water Channels)IBA
08/2013
1Coal (Coals)IBA
02/2013
1Coal Tar (Estar)IBA
02/2013
1Keratin-17 (Keratin 17)IBA
07/2012
1Interleukin-1 (Interleukin 1)IBA
04/2012
1Peptide Hydrolases (Proteases)FDA Link
04/2012
1Urocanic AcidIBA
01/2012
1Steryl-Sulfatase (Steroid Sulfatase)IBA
12/2011
1Hair-Specific Keratins (Keratins, Hair Specific)IBA
10/2011
1Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
05/2011
14- Acetamido- 4'- isothiocyanatostilbene- 2,2'- disulfonic Acid (SITS)IBA
01/2011
1HLA-C Antigens (HLA-C)IBA
11/2010
1Nucleic AcidsIBA
09/2009
1AntigensIBA
05/2009
1Proline (L-Proline)FDA Link
03/2009
1involucrinIBA
03/2009
1Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
09/2008
1Serine Proteases (Serine Protease)IBA
09/2008
1SteroidsIBA
09/2008
1rat KLK7 proteinIBA
09/2008
1Serine Peptidase Inhibitor Kazal-Type 5IBA
09/2008
1Albuterol (Salbutamol)FDA LinkGeneric
09/2008

Therapy/Procedure

7Therapeutics
03/2016 - 03/2008
1Slit Lamp
03/2016
1Precision Medicine
02/2014
1Traditional Medicine (Folk Remedies)
02/2013
1RNAi Therapeutics
06/2012
1Intravenous Injections
05/2009
1Hair Removal (Depilation)
02/2009